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KMID : 1161420220250070695
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Journal of Medicinal Food
2022 Volume.25 No. 7 p.695 ~ p.709
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The Protein-Rich Fraction from Spirulina platensis Exerts Neuroprotection in Hemiparkinsonian Rats by Decreasing Brain Inflammatory-Related Enzymes and Glial Fibrillary Acidic Protein Expressions
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Lopes Maria Janice Pereira
de Araujo Delmondes Gyllyandeson
de Lacerda Leite Giovana Mendes
Cavalcante Debora Rejane Alves
de Aquino Pedro Everson Alexandre
de Lima Francisco Arnaldo Viana
Neves Kelly Rose Tavares
Costa Andrea Santos
de Oliveira Hermogenes David
de Barros Viana Glauce Socorro
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Abstract
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Spirulina platensis is a cyanobacterium with high protein content and presenting neuroprotective effects. Now, we studied a protein-enriched fraction (SPF), on behavior, neurochemical and immunohistochemical (IHC) assays in hemiparkinsonian rats, distributed into the groups: SO (sham-operated), 6-hydroxydopamine (6-OHDA), and 6-OHDA (treated with SPF, 5 and 10?mg/kg, p.o., 15 days). Afterward, animals were subjected to behavioral tests and euthanized, and brain areas used for neurochemical and IHC assays. SPF partly reversed the changes in the apomorphine-induced rotations, open field and forced swim tests, and also the decrease in striatal dopamine and 3,4-dihydroxyphenylacetic acid contents seen in hemiparkinsonian rats. Furthermore, SPF reduced brain oxidative stress and increased striatal expressions of tyrosine hydroxylase and dopamine transporter and significantly reduced hippocampal inducible nitric oxide synthase, cyclooxygenase-2 and glial fibrillary acidic protein expressions. The data suggest that the protein fraction from S. platensis, through its brain anti-inflammatory and antioxidative actions, exerts neuroprotective effects that could benefit patients affected by neurodegenerative diseases, like Parkinson's disease.
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KEYWORD
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hemiparkinsonian rats, immunohistochemical assays, neuroprotection, oxidative stress, phycocyanin, Spirulina platensis
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